Department of Genetics and Infertility Treatment
Whenever a couple do not succeed in trying to have a pregnancy with sufficient sexual intercourse within a year (without using a contraceptive method), they are called infertile couples. Today, different methods are used to treat infertility. One of the amazing advances in infertility is Assisted Reproductive Technique (ART).
Depending on the problem of infertile couples, they will be provided with a variety of services, including Intra Cytoplasmic Sperm Injection (ICSI), Micro Immunization, Preimplantation Genetic Diagnosis (PGD), and Intra Uterine Insemination (IUI).
The causes of infertility that require the following fertility methods are:
- Sperm disorder (male sperm in terms of number, mobility, or shape does not have the required quality
- The presence of anti-sperm substance in the semen and female genital system
- The cases that require the extraction of sperm by sampling the testicles (testicular biopsy) and seminal tubes
- The introduction of sperm into the bladder in patients with neurological lesions
- Sperm samples are taken in patients with spinal cord injury by electric arousal or a vibrator
- Sperm that does not penetrate the ovum
- Ovulation disorders
- Cervical and uterine problems
- The closure of the uterine tubes
- Congenital anomalies and female genital sticks
- The cases where the shell around the ovum is thick
- The cases that need to identify the gender of the fetus before the implantation
- The cases to ensure that there are no abnormalities of the fetus before implantation
- Infertility with unknown causes
Microinjection means the injection of sperm into the ovum cytoplasm and is one of the most effective methods of assisting in the treatment of infertility. Artificial fecundation is the intraocular fertilization of the ovum and the sperm, which can be divided into four stages of artificial fecundation or microinjection:
Stage One: Controlled ovary stimulation
Stage II: Ovulation
Stage III: Sperm and ovum fertilization in the laboratory and fetal development
Stage Four: Embryos to the womb
Freezing of the fetus:
If after the embryo transfer, there are additional embryos of good quality, they are frozen and kept with the satisfaction of the couples. The amount of pregnancy by using frozen fetus (by freezing glassy) is as good as the use of fresh fetus.
This method is relatively simple and painless and can be performed without anesthesia. In this method, after the initial examination and washing the male sperm sample, the healthy and active sperm are separated and injected into the uterine cavity. In the natural intercourse, about 10% of the sperm reaches the cervix from the vagina, but in the process of intrauterine insemination, more sperm can reach the uterus with proper quality.
Genetic Detection Before Implantation:
Increasing the age of the mother and the presence of genetic diseases in high-risk couples can increase the risk of chromosomal abnormalities in the baby. . Performing this process requires artificial insemination or microinjection. In this method, the fetus formed in the laboratory is biopsied on the third day when it is in the 8th cell, and one or two blastomers are separated from it and then evaluated genetically by specific coloring methods.